منابع مشابه
Why Do Some Primate Malarias Relapse?
Relapse may have evolved in malaria as a mechanism to avoid suppression by more virulent species in mixed infections, thereby increasing transmission opportunities. Later evolution of long latency in Plasmodium vivax was a necessary adaptation as early hominins moved to colder areas with shorter mosquito breeding seasons. Genetic diversity was maintained through heterologous hypnozoite activation.
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Most malaria diagnosed outside endemic zones occurs in patients experiencing the consequences of what was likely a single infectious bite by an anopheline mosquito. A single species of parasite is nearly always involved and expert opinion on malaria chemotherapy uniformly prescribes species- and stage-specific treatments. However the vast majority of people experiencing malaria, those resident ...
متن کاملStudies on the Chemotherapy of the Human Malarias
The relative effectiveness of the various cinchona alkaloids in the treatment of malaria has been the subject of numerous investigations since the meeting of the Madras Commission in 1868 (1). Without exception, studies undertaken prior to the recent war involved the appraisal of the comparative antimalarial activities of quinine, quinidine, cinchonine and cinchonidine on the basis of the oral ...
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Protozoans within the genus Plasmodium are well-known as the causative agents of malaria in humans. Numerous Plasmodium species parasites also infect a wide range of non-human primate hosts in tropical and sub-tropical regions worldwide. Studying this diversity can provide critical insight into our understanding of human malarias, as several human malaria species are a result of host switches f...
متن کاملChemotherapeutics challenges in developing effective treatments for the endemic malarias.
The endemic malarias threaten the several billion people residing where transmission occurs. Chemotherapeutic strategy pitted against these threats hinges upon species- and stage-specific treatments guided by diagnosis and screening against sometime dangerous contraindications. This approach suits malaria as it occurs among travelers in the developed, non-endemic world. However, limiting treatm...
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ژورنال
عنوان ژورنال: The Lancet
سال: 2004
ISSN: 0140-6736
DOI: 10.1016/s0140-6736(04)15879-0